Synthesis of indole-annulated sulfur heterocycles using copper-catalysed C-N coupling and palladium-catalysed direct arylation.
نویسندگان
چکیده
A simple and efficient method for the synthesis of biologically relevant 5H-benzo[4,5][1,3]thiazino[3,2-a]indoles and 5,7-dihydroisothiochromeno[3,4-b]indoles has been developed via intramolecular copper catalysed Ullmann-type C-N coupling and palladium catalysed direct arylation from the corresponding precursors 2-(2-bromobenzylthio)-1H-indole and 2-(2-bromobenzylthio)-1-methyl-1H-indole, respectively, in good to excellent yields.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 13 شماره
صفحات -
تاریخ انتشار 2016